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The Best Episodes of Grey's Anatomy Season 4

Every episode of Grey's Anatomy Season 4 ranked from best to worst. Discover the Best Episodes of Grey's Anatomy Season 4!

Binge this in 12h 11m•Peaking at 8.8/10

Follows the personal and professional lives of a group of doctors at Seattle's Grey Sloan Memorial Hospital.

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Episode Rankings

  1. #1 Fan Favorite
    Grey's Anatomy Season 4 Episode 1 - A Change Is Gonna Come
    8.0/10(1606 votes)

    #1 - A Change Is Gonna Come

    S4:E1

    Entering their first year as residents, Meredith Grey, Cristina Yang, Izzie Stevens and Alex Karev now have interns of their own to mentor. Among the new interns are George, forced to repeat his internship after failing his exams, and Lexie Grey, Meredith's half-sister. Another two new interns will be introduced in this season premiere. And they'll have their hands full when a three-car accident sends multiple casualties pouring into Seattle Grace. Some of the doctors need to deal with new stressed out interns. A young boy brings his bleeding deer to the hospital in the hope a doctor will save her.

    Directors:Michael Grossman, Rob Corn
    Writer:Shonda Rhimes

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  2. Grey's Anatomy Season 4 Episode 2 - Love/Addiction
    7.7/10(1403 votes)

    #2 - Love/Addiction

    S4:E2

    A patient is in the hospital because they fell asleep in a hazardous situation. A patient's home laboratory blew up in an apartment building and the victims flood the hospital. Alex investigates the cause of the incident by talking to a really old guy who lived in the building. Jane Burke shows up to deal with what her son left behind. Lexie tries to talk to Meredith. Callie is overwhelmed by her new position while Bailey is searching for things to do.

    Director:James Frawley
    Writer:Debora Cahn

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  3. Grey's Anatomy Season 4 Episode 3 - Let the Truth Sting
    7.9/10(1425 votes)

    #3 - Let the Truth Sting

    S4:E3

    The doctors meet the world's oldest intern. Marcy brings in her son Henry because she finds his change in behavior suspicious. A patient named Connie may lose her vocal chords unless Mark and Richard can perform a radical new surgery. George impresses the other interns at work but at home he is trying to deal with his guilt about having sex with Izzie.

    Director:Daniel Minahan
    Writer:Mark Wilding

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  4. Grey's Anatomy Season 4 Episode 4 - The Heart of the Matter
    7.9/10(1452 votes)

    #4 - The Heart of the Matter

    S4:E4

    A face familiar to one of the year-twos shows up and dredges up issues that were never really dealt with. A teen soccer player needs counseling because of his father and surgery for an injury he sustained while playing the game. Another patient's, named Courtney, finds out that her cancer is back.

    Director:Randall Zisk
    Writer:Allan Heinberg

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  5. Grey's Anatomy Season 4 Episode 5 - Haunt You Every Day
    7.9/10(1420 votes)

    #5 - Haunt You Every Day

    S4:E5

    It's Halloween at Seattle Grace! There may be jokes, pranks, and/or scare tactics. Some of the women form a club based on an experience they all share. A man volunteers for what most of the doctors believe is an unnecessary surgery. One of the patients is in the hospital because they tried to carve a pumpkin in an unconventional manner.

    Director:Bethany Rooney
    Writer:Krista Vernoff

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  6. Grey's Anatomy Season 4 Episode 6 - Kung Fu Fighting
    7.8/10(1361 votes)

    #6 - Kung Fu Fighting

    S4:E6

    A patient comes to the ER with a dream and a condition which may prevent him form realizing it. Two patients are competing to win something big. One of them convinces an intern to take their place.

    Director:Tom Verica
    Writer:Stacy McKee

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  7. Grey's Anatomy Season 4 Episode 7 - Physical Attraction, Chemical Reaction
    7.7/10(1398 votes)

    #7 - Physical Attraction, Chemical Reaction

    S4:E7

    Izzie and George's new-founded relationship results in them having bad sex. Callie's Chief Resident position is taken away from her, and Bailey is the humble replacement. Meredith can barely handle it with Lexie anymore.

    Director:Jeff Melman
    Writer:Joan Rater

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  8. Grey's Anatomy Season 4 Episode 8 - Forever Young
    7.9/10(1436 votes)

    #8 - Forever Young

    S4:E8

    There has been a bus crash and the patients are in the ER. Meredith and Derek's relationship gets more complicated when he dates a fellow doctor. Meredith's dad goes to visit her at the hospital.

    Directors:Tom Verica, Rob Corn
    Writer:Mark Wilding

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  9. Grey's Anatomy Season 4 Episode 9 - Crash Into Me (1)
    8.5/10(1594 votes)

    #9 - Crash Into Me (1)

    S4:E9

    An ambulance crash endangers the lives of the paramedics involved, as Meredith and the Chief work on-site to save them, Bailey treats a patient who refuses her help, and Ava returns for Alex and meets his other girlfriend in the process.

    Director:Michael Grossman
    Writers:Krista Vernoff, Shonda Rhimes

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  10. Grey's Anatomy Season 4 Episode 10 - Crash Into Me (2)
    8.4/10(1514 votes)

    #10 - Crash Into Me (2)

    S4:E10

    Meredith works furiously to save a paramedic trapped in an ambulance; Lexie holds the life of a patient in her hands; Derek must rely on a nurse to save a patient; Bailey struggles to balance her personal life with her work.

    Director:Jessica Yu
    Writers:Krista Vernoff, Shonda Rhimes

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  11. Grey's Anatomy Season 4 Episode 11 - Lay Your Hands on Me
    7.9/10(1416 votes)

    #11 - Lay Your Hands on Me

    S4:E11

    George has a surprise visitor. Bailey's family is falling apart. Derek sorts through what kissing Rose means. Meredith discovers something that doesn't inspire hope or happiness in her. Alex treats a faith healer.

    Director:John Terlesky
    Writer:Allan Heinberg

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  12. Grey's Anatomy Season 4 Episode 12 - Where The Wild Things Are
    8.0/10(1364 votes)

    #12 - Where The Wild Things Are

    S4:E12

    Time has passed but not much has changed. Sexual angst still runs rampant in the halls of Seattle Grace. Derek and Rose have been dating and Meredith has noticed the activities of her current off-again ex-boyfriend. The doctor's are in the midst of a competition.

    Director:Rob Corn
    Writer:Zoanne Clack

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  13. Grey's Anatomy Season 4 Episode 13 - Piece of My Heart
    8.1/10(1379 votes)

    #13 - Piece of My Heart

    S4:E13

    Addison visits Seattle Grace because they need skills that only she has. Rebecca/Ava returns with news for Alex. Meredith and Derek's clinical trial experiences one or two developments.

    Director:Mark Tinker
    Writer:Stacy McKee

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  14. Grey's Anatomy Season 4 Episode 14 - The Becoming
    8.0/10(1571 votes)

    #14 - The Becoming

    S4:E14

    The clinical trial continues to make progress. The anti-McSteamy club creates new initiatives but that isn't enough to stop one woman from spending time with him. Christina is affected by Burke's career developments.

    Director:Julie Anne Robinson
    Writer:Joan Rater

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  15. Grey's Anatomy Season 4 Episode 15 - Losing My Mind
    8.0/10(1425 votes)

    #15 - Losing My Mind

    S4:E15

    Dr. Wyatt refuses to let Meredith give up on therapy. Alex learns something else about Rebecca. The Chief wants Erica to perform a daring surgery. Christina continues to act strangely.

    Director:James Frawley
    Writer:Debora Cahn

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  16. Grey's Anatomy Season 4 Episode 16 - Freedom (1)
    8.6/10(1788 votes)

    #16 - Freedom (1)

    S4:E16

    A couple undergoes surgery. Derek and Meredith's clinical trial gets a second shot from a new patient. Izzie helps Alex. McSteamy hooks up with someone.

    Director:Rob Corn
    Writer:Shonda Rhimes

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  17. Grey's Anatomy Season 4 Episode 17 - Freedom (2)
    8.8/10(1494 votes)

    #17 - Freedom (2)

    S4:E17

    A couple undergoes surgery. Derek and Meredith's clinical trial gets a second shot from a new patient. Izzie helps Alex. McSteamy hooks up with someone.

    Director:Rob Corn
    Writer:Shonda Rhimes

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Season 4 Ratings Summary

"A Change Is Gonna Come" is the best rated episode of "Grey's Anatomy" season 4. It scored 8/10 based on 1606 votes. Directed by Michael Grossman, Rob Corn and written by Shonda Rhimes, it aired on 9/27/2007. This episode is rated 0.3 points higher than the second-best, "Love/Addiction".