Jo, Natalie and Blair are going to New York to see a Broadway play and a left out Tootie sneaks out to meet them in front of the theatre without Mrs. Garrett's knowledge. However, when Tootie doesn't find the girls she stops in a coffee shop across the street unaware she's about to get a dose of the downside of New York life.

It's finals week at Eastland and the girls are planning an all night study session. They soon find out that studying is going to be hard with so many distractions, including Blair and Jo's fears of the future in college and Natalie's fear of an upcoming Chemistry exam in which she must memorize the atomic symbols.

Natalie has a big crush on Tim and has filled Blair's slambook with words of praise. However, in Blair's slambook instead of signing your name you sign a number, Natalie's number is 10. When Blair tells Tim who number 10 belongs to, Natalie is furious and wants revenge no matter who she hurts in the process.

As graduation day arrives, Monica is furious that Blair's father won't attend, Rose is furious at Charlie due to his sudden tranformation into a big spender and Natalie and Tootie are scared that they will lose Blair and Jo as friends when they leave for college.

The holidays bring joy to the girls when they all plan on going home for Christmas but when Jo's mother temporarily moves to Miami, Jo is stuck in Peekskill.

Jo begins a pizza business with her mom's secret pizza recipe that has everyone's mouths watering, including a fraternity house that buys pizzas in bulk. However, the business begins running Jo and her workers, Natalie and Tootie ragged which leads Jo to make a business decision on how to make pizzas faster and cheaper.

Constant squabbling between the girls prompt Mrs. Garrett to announce that the debt for wrecking the van has been paid off and they are all now free to move out and live in the dorms. However, the girls soon realize the living above the cafeteria is something they do not want to change.

Graduation has everyone rushing around and Natalie and Tootie are worried that their isn't going to be enough time for Jo and Blair to say goodbye, especially since Blair and Jo are at each other's throats, as usual.

Jo and Blair have a hard time adjusting to college.

Ms Garret decides to re-open an abandoned department store and turn it into her own.

A strange man tells the girls that years ago a murder occurred in the shop. Later, when the girls see Mrs. Garret with a knife they assume that she's possessed by the murderer's spirit and is out to get them.

Natalie starts dating a black guy, and Tootie thinks that Natalie hates him because of his color.

Blair is devastated when she learns that her boyfriend is into cocaine. Lisa Whelchel. Jo: Nancy McKeon. Kevin: Ryan Cassidy. Father Donovan: John Ingle.

Both Blair and Jo head to New York to meet two old friends. Blair discovers her old friend, Dina, is the same old snob she's always been and Jo discovers her friend, Jesse, is the same old prejudiced bully she's always been. Blair and Jo soon realize their friendship is much more meaningful.

Mrs. Garrett and the girls all become concerned about Blair's bizarre behavior, she's skipping class, dating nonstop and is out all night every night, all this just after a breakup with her first serious relationship, Cliff.

The girls have no plans for spring break until Natalie learns that her grandmother's condominium is available in Fort Lauderdale, where the boys are.

The local drive-in theatre is closing and the girls decide to pay it one last visit on the final night it's open. However, chaos reigns when people begin to loot the theatre and Blair gets into a cat fight.

On the day Blair is to accept an award, she encounters two burdens. First, she's stuck babysitting her baby brother and second she becomes trapped in an elevator, where she learns an important lesson from a concentration camp survivor.

Mrs. Garrett and the girls visit New York and have lunch in a Italian restaurant where Natalie discovers something she never expected, her father romancing someone other than her mother. This prompts Natalie to debate whether or not to confront her father, out of fear of a divorce between her parents.

Natalie makes up a source for the topic of her newspaper article on abortion and if she doesn't reveal who the source is, she could be kicked out of school. However, little does she know, that their is someone at Eastland who could fill the shoes of the ""made up source""

The girls are shaken by the sudden death of Natalie's father and wonder how to ease her pain.

On a dateless Saturday night, the girls cruise downtown Peekskill in hopes of finding Mr. Right. However, a string of bizarre events leads the girls to hideout in their car at a closed gas station.

During an alumni weekend at Langley, Blair's mother and Jo's father bond which leads to Blair and Jo's fears of becoming sisters.

Tootie's learning to drive and she's driving everyone bananas.

Burned by her journalism teacher's scathing criticism, Jo turns out a front-page story linking him to a drug bust.