Nothing means more to Chris than his relationship with his daughter, Zoey, but now he feels he is failing her as his weight gain begins to limit his mobility. Chris turns to his mother, whom he hasn't seen in seven years, to help get his life on track.

Twins Kandi & Brandi have a combined weight totaling over 1100lbs. These inseparable twins fear losing each other to obesity, so they make a change together. But a life-threatening event during weight loss surgery recovery may separate them forever.

A college graduate with a once-promising career, Justin has eaten his life away to the point of never leaving the house for anything but food; only the help of Dr. Now's weight-loss program can restore his hopes of living a happy, productive life.

Fearing that he'll suffer the same fate as older brother David, now 700 pounds and unable to work, Benji hopes to be able to support both himself and his brother on their life-or-death weight loss journey.

Growing up in foster care, David suffered from a lack of attention and didn't develop a sense of self-worth. Now he weighs 800 pounds, and he's relying on his favorite foster mom to support him as he finds the motivation to change and save his own life.

Battling severe depression in the wake of a suicide attempt, 46-year old Olivia hasn't left her Chicago basement in two years. With one last chance at a new life, Olivia will travel to Houston with the hope of having a life-changing surgery.

Now bedridden and unable to care for herself, Lisa must find a way to lose the weight or she will never see her grandchildren grow up.

Lacey is so big from overeating that she can barely leave the house, but that hasn't stopped her from finding love with Ricky. Her weight isn't the only thing between her and a happy husband, however, with Ricky's sister Sharon in the picture.

With her weight spiraling, Stephanie needs her mom's help to care for her three kids. Now, she's at the point where she'll have to lose weight or risk not having the chance to see her kids grow up.

650-lb Melissa begins her seven-year weight loss journey.

650-lb Melissa struggles to get to her ideal weight.

750-lb Henry begins his weight loss journey in the hopes of transforming himself in time to attend his high school reunion.

Weighing over 600 lbs. each, Vianey and Allen are locked in a codependent relationship based on a shared love of food. As they head to Houston, they will soon find out if their relationship can handle the strain of growing healthy together.

As an Italian American, Geno was raised with lots of love, family and food. Now, he's still living with his mom and eating himself to death, and it's time to make a change. Geno's cousin, Nico, joins the cause, and they pledge to lose weight together.

Latonya found the man she wants to marry. The only problem is that, at almost 700 pounds, she can't walk down the aisle. Latonya doesn't want to give up the food that she's used to, but will she do it for love?

At 42 years old, Angel is staring death in the face. She is struggling to make a positive change and be an active part of her partner and son's lives. With so much at stake, can she turn her life around?

Melissa has lost 500 pounds and saw her weight drop to 137 pounds, but now faces marital problems and life as a single mom, all while struggling with a gain of 150 pounds.

Kelly is on the verge of immobility when she decided to make the trip to Houston to visit Dr. Now; Her journey gets off to a painful start when a long travel day grows longer as Kelly gets stuck in a cab on her way from the clinic to the hospital.

Cillas' food addiction is getting in the way of his ability to be there for his fiancée, Jessica, and her three daughters; if he doesn't lose weight soon, he knows he'll lose either his girls or his life.

J.T. is almost 900lbs with a 100-lb lymphedema mass on his leg and a food addiction that is bound to kill him if he doesn't change. His girlfriend takes him to Houston, but when his behavior drives her away, J.T. is left with only Dr. Now to help.

Living on a homestead with his family, Lucas wants to spread his wings and fly, but at 600 pounds, he can't take off. All he does is eat and game, and if he wants to leave the nest and live a normal life, he needs Dr. Now's help to lose over 400 pounds.

Zsaylnn, once known as the "Fat Girl Rock Star" - married a man who loves large women. Now weighing over 600lbs, she urgently needs to lose weight to be the mother her daughter deserves. Can Zsalynn succeed with a husband who doesn’t support her goals?

Chuck weighs almost 700lbs and it has hindered every aspect of his life. He's had to downsize his business and his wife feels like a single-parent, who is ready to leave him. Can Chuck take control and reclaim the life that's slipping through his fingers?

Nikki's life and career are threatened by her 650-pound weight. Determined to make a change, she undergoes weight-loss surgery.

Brandon is a talented musician with a beautiful voice and a run-away weight problem; he wants to lose weight and embark on a career; he also wants to take the next step with his girlfriend, Taylor, whom he risks losing if he can't make a change.